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Lack of association of histamine-N-methyltransferase (HNMT) polymorphisms with asthma in the Indian population.

Authors: Sharma, S  Mann, D  Singh, TP  Ghosh, B 
Citation: Sharma S, etal., J Hum Genet. 2005;50(12):611-7. Epub 2005 Oct 5.
Pubmed: (View Article at PubMed) PMID:16205835
DOI: Full-text: DOI:10.1007/s10038-005-0302-4

Histamine plays a major role in allergic disorders, including asthma. A major pathway of histamine biotransformation in the lungs is mediated by histamine N-methyltransferase (HNMT). We investigated the association of a functional SNP C314T; a SNP A929G, a (CA)n repeat in intron 5, and a novel (CA)n repeat (BV677277), 7.5 kb downstream of the HNMT gene with asthma and its associated traits such as total serum IgE levels in a case-control as well as in a family-based study design. In contrast to a previous study, no association was observed for the polymorphisms investigated with asthma (P>0.05). When haplotypes were constructed for these loci and compared, no significant difference was observed in the distribution between cases and controls. In the family-based design, no biased transmission was observed for any of the polymorphisms and haplotypes with asthma using the additive model of inheritance in family-based association test (FBAT). Thus, consistent with the case-control findings, the polymorphisms and haplotypes in the HNMT gene are not associated with asthma in the Indian population.


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CRRD Object Information
CRRD ID: 5128887
Created: 2011-03-22
Species: All species
Last Modified: 2011-03-22
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.