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Familial Mediterranean fever gene and protection against asthma.

Authors: Rabinovitch, E  Harats, D  Yaron, P  Luvish, T  Lidar, M  Kedem, R  Shaish, A  Ben-Dov, I  Livneh, A 
Citation: Rabinovitch E, etal., Ann Allergy Asthma Immunol. 2007 Dec;99(6):517-21.
Pubmed: (View Article at PubMed) PMID:18219832
DOI: Full-text: DOI:10.1016/S1081-1206(10)60380-8

BACKGROUND: Asthma is an inflammatory airway disease caused by interaction between susceptibility genes and diverse environmental factors. In Israel, asthma seems to be familial and more severe in patients of Iraqi Jewish descent. On the other hand, asthma is less frequent in individuals with familial Mediterranean fever, an autoinflammatory disease prevalent in the Iraqi Jewish community and linked to mutations in the familial Mediterranean fever gene, designated MEFV. OBJECTIVES: To explore a possible role for mutated MEFV in the reduced susceptibility to asthma and to determine its expression in Israeli subjects of Iraqi origins. METHODS: Using a case-control approach, we studied the presence of the 3 most common MEFV mutations (M694V, V726A, and E148Q) in DNA samples from 75 patients with asthma and 45 asymptomatic first-degree relatives, all of Iraqi Jewish origin. The severity of asthma was evaluated using a published severity score. RESULTS: Eleven patients with asthma and 14 of their relatives carried 1 or 2 mutations in the MEFV gene, a carrier rate significantly lower in patients with asthma than in their first-degree relatives and in ethnically matched healthy individuals (P < .03 and P < .003, respectively). Carriers of MEFV mutations had less severe disease, compared with noncarriers (P < .002). CONCLUSION: These findings suggest that MEFV mutations may have a protective effect in the pathogenesis of asthma.


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CRRD Object Information
CRRD ID: 5129186
Created: 2011-03-28
Species: All species
Last Modified: 2011-03-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.