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Complement components (C3, C4) as inflammatory markers in asthma.

Authors: Abdel Fattah, M  El Baz, M  Sherif, A  Adel, A 
Citation: Abdel Fattah M, etal., Indian J Pediatr. 2010 Jul;77(7):771-3. Epub 2010 Jun 29.
Pubmed: (View Article at PubMed) PMID:20589464
DOI: Full-text: DOI:10.1007/s12098-010-0117-y

OBJECTIVE: To assess the serum levels of complement factors C3 and C4 in Egyptian asthmatic children. METHODS: This case-controlled study comprised of 60 Egyptian children with the diagnosis of bronchial asthma (not in acute attack) and 60 age-and sex-matched healthy controls. All candidates were subjected to a thorough clinical study, complete blood counts, absolute eosinophil count and serum complements (C3, C4). RESULTS: Serum C3 was significantly higher in asthmatics when compared to controls (140.60 +/- 38.80 mg/dl vs 107.70 +/- 45.00 mg/dl respectively, (p = 0.01). However, differences in serum C4 levels were not significant (41.30+/-48.80 mg/dl vs 44.60 +/- 39.70 mg/dl respectively, p = 0.69). There was a significant positive correlation between severity of asthma and serum C3 (p=0.02) but not with serum C4. CONCLUSIONS: Serum levels of C3 - but not C4 - are elevated in children with stable asthma, with a positive correlation between serum C3 and severity of asthma.

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CRRD Object Information
CRRD ID: 5129519
Created: 2011-04-01
Species: All species
Last Modified: 2011-04-01
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.