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Correlation of plasma complement split product levels with allergic respiratory disease activity and relation to allergen immunotherapy.

Authors: Bowser, C  Erstein, DP  Silverberg, JI  Nowakowski, M  Joks, R 
Citation: Bowser C, etal., Ann Allergy Asthma Immunol. 2010 Jan;104(1):42-9.
Pubmed: (View Article at PubMed) PMID:20143644
DOI: Full-text: DOI:10.1016/j.anai.2009.11.021

BACKGROUND: Allergens, including dust mite and grass pollen, and mast cell tryptase are known to generate the complement split products (CSPs) C5a and C3a, which can then trigger allergic inflammation. The relation of these anaphylatoxin levels to clinical allergic disease responses is not known. OBJECTIVE: To evaluate the relationship of plasma CSP levels to allergic respiratory disease variables in an adult cohort. METHODS: A cross-sectional survey was used to assess the association of plasma C5a desArg and C3a desArg levels with clinical allergic respiratory disease variables. Furthermore, a time course of the effect of routine allergen immunotherapy on plasma CSP levels and cutaneous and pulmonary responses was determined. RESULTS: Adult plasma C5a desArg levels correlate with asthma severity as determined by a physician (P = .01) and by Asthma Quality of Life Questionnaire scores (P < .01). Change in plasma C5a desArg levels 1 hour after immunotherapy is associated with baseline rhinoconjunctivitis symptom severity (P = .03), change in total mean wheal diameter (P = .05), and total dust mite dosage (P = .04). Change in plasma C3a desArg levels 3 hours after immunotherapy correlates with change in total mean wheal diameter induced by dust mite (P = .01). Change in plasma CSP levels after immunotherapy did not correlate with change in spirometric outcome. CONCLUSIONS: Plasma C5a desArg levels reflect allergic respiratory disease severity as assessed by physicians and correlate with Asthma Quality of Life Questionnaire scores. Changes in CSP levels after immunotherapy reflect cutaneous allergic responses, especially to dust mite allergen.


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CRRD Object Information
CRRD ID: 5129706
Created: 2011-04-05
Species: All species
Last Modified: 2011-04-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.