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Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis.

Authors: Carvalho, A  Pasqualotto, AC  Pitzurra, L  Romani, L  Denning, DW  Rodrigues, F 
Citation: Carvalho A, etal., J Infect Dis. 2008 Feb 15;197(4):618-21.
Pubmed: (View Article at PubMed) PMID:18275280
DOI: Full-text: DOI:10.1086/526500

Toll-like receptors (TLRs) are important components of innate immunity. We investigated the association between polymorphisms in the TLR2, TLR4, and TLR9 genes and susceptibility to noninvasive forms of pulmonary aspergillosis. A significant association was observed between allele G on Asp299Gly (TLR4) and chronic cavitary pulmonary aspergillosis (odds ratio [OR], 3.46; P =.003). Susceptibility to allergic bronchopulmonary aspergillosis was associated with allele C on T-1237C (TLR9) (OR, 2.49; P =. 043). No particular polymorphism was associated with severe asthma with fungal sensitization. These findings reinforce the importance of innate immunity in the pathogenesis of different forms of aspergillosis.


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CRRD Object Information
CRRD ID: 5130863
Created: 2011-04-13
Species: All species
Last Modified: 2011-04-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.