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Nonasthmatic nasal polyposis patients with allergy exhibit greater epithelial MMP positivity.

Authors: Shin, HW  Han, DH  Lim, YS  Kim, HJ  Kim, DY  Lee, CH  Min, YG  Rhee, CS 
Citation: Shin HW, etal., Otolaryngol Head Neck Surg. 2009 Oct;141(4):442-7.
Pubmed: (View Article at PubMed) PMID:19786210
DOI: Full-text: DOI:10.1016/j.otohns.2009.07.011

OBJECTIVE: To determine the influence of allergic rhinitis (AR) on the expression of matrix metalloproteinase (MMP)-9, MMP-2, and tissue inhibitor-1 of metalloproteinase (TIMP-1) in nasal polyposis. STUDY DESIGN: A case-control study. SETTING: A tertiary referral center. SUBJECTS AND METHODS: The expression of MMP-9, MMP-2, and TIMP-1 was investigated in the nasal polyp tissue (NP) and maxillary sinus mucosa (MM) samples from 20 AR patients and 20 nonallergic patients undergoing endoscopic sinus surgery. Trichrome, periodic acid-Schiff, and hematoxylin-eosin staining were also performed and those expression levels were compared. RESULTS: Infiltration of eosinophils was shown more intensely in NP rather than in MM, especially in the presence of AR. In the NP of AR patients, increased expression of MMP-9, MMP-2, and TIMP-1 was observed more prominently than in that of the control group. In case of MM, however, there was no significant difference between AR patients and the control group. CONCLUSION: The presence of AR may enhance the expression of MMP-9, MMP-2, and TIMP-1 associated with airway remodeling in nasal polyposis.

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CRRD Object Information
CRRD ID: 5130872
Created: 2011-04-13
Species: All species
Last Modified: 2011-04-13
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.