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NOD1 variation, immunoglobulin E and asthma.

Authors: Hysi, P  Kabesch, M  Moffatt, MF  Schedel, M  Carr, D  Zhang, Y  Boardman, B  Von Mutius, E  Weiland, SK  Leupold, W  Fritzsch, C  Klopp, N  Musk, AW  James, A  Nunez, G  Inohara, N  Cookson, WO 
Citation: Hysi P, etal., Hum Mol Genet. 2005 Apr 1;14(7):935-41. Epub 2005 Feb 17.
Pubmed: (View Article at PubMed) PMID:15718249
DOI: Full-text: DOI:10.1093/hmg/ddi087

Asthma is a familial inflammatory disease of the airways of the lung. Microbial exposures in childhood protect against asthma through unknown mechanisms. The innate immune system is able to identify microbial components through a variety of pattern-recognition receptors (PRRs). NOD1 is an intracellular PRR that initiates inflammation in response to bacterial diaminopimelic acid (iE-DAP). The NOD1 gene is on chromosome 7p14, in a region that has been genetically linked to asthma. We carried out a systematic search for polymorphism in the gene. We found an insertion-deletion polymorphism (ND(1)+32656) near the beginning of intron IX that accounted for approximately 7% of the variation in IgE in two panels of families (P<0.0005 in each). Allele*2 (the insertion) was associated with high IgE levels. The same allele was strongly associated with asthma in an independent study of 600 asthmatic children and 1194 super-normal controls [odds ratio (OR) 6.3; 95% confidence interval (CI) 1.4-28.3, dominant model]. Differential binding of the two ND(1)+32656 alleles was observed to a protein from nuclei of the Calu 3 epithelial cell line. In an accompanying study, the deletion allele (ND(1)+32656*1) was found to be associated with inflammatory bowel disease. The results indicate that intracellular recognition of specific bacterial products affects the presence of childhood asthma.

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CRRD Object Information
CRRD ID: 5131518
Created: 2011-05-02
Species: All species
Last Modified: 2011-05-02
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.