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Genetic variation in CRTh2 influences development of allergic phenotypes.

Authors: Cameron, L  Depner, M  Kormann, M  Klopp, N  Illig, T  Von Mutius, E  Kabesch, M 
Citation: Cameron L, etal., Allergy. 2009 Oct;64(10):1478-85. Epub 2009 Apr 14.
Pubmed: (View Article at PubMed) PMID:19392992
DOI: Full-text: DOI:10.1111/j.1398-9995.2009.02053.x

BACKGROUND: Allergic disorders are characterized by an increase in the Th2 cytokines IL-4, IL-5 and IL-13, produced primarily by Th2 cells. These cells are marked by the expression of CRTh2 (chemoattractant receptor-homologous molecule expressed on Th2 cells), a receptor for prostaglandin D(2). As genetic variation plays a significant role in the predisposition for allergic disorders, we investigated the influence of single nucleotide polymorphisms (SNPs) in CRTh2. METHODS: In a large study population of German children (n = 4264) from the International Study of Asthma and Allergy in Children (ISAAC II), six polymorphisms in CRTh2 were genotyped. Statistical analyses were performed using single SNP and haplotype analyses. RESULTS: Uncorrected associations among -6373G>A, +1431G>C and +1538A>G were observed with a number of allergic phenotypes (P < 0.05). After correction, association between +1431C and specific IgE to food allergens remained significant (P = 0.04). Associations of haplotype (H)3 (containing +1538G) with reduced risk for asthma and H2 (containing +1431C) with increased risk for specific IgE to food allergens also remained significant after correction for multiple testing (P = 0.004). CONCLUSIONS: Genetic variation within CRTh2 modifies the development of allergic sensitization and asthma in a population of German children.


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CRRD Object Information
CRRD ID: 5135019
Created: 2011-07-08
Species: All species
Last Modified: 2011-07-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.