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Bronchial mucosal inflammation and upregulation of CXC chemoattractants and receptors in severe exacerbations of asthma.

Authors: Qiu, Y  Zhu, J  Bandi, V  Guntupalli, KK  Jeffery, PK 
Citation: Qiu Y, etal., Thorax. 2007 Jun;62(6):475-82. Epub 2007 Jan 18.
Pubmed: (View Article at PubMed) PMID:17234659
DOI: Full-text: DOI:10.1136/thx.2006.066670

BACKGROUND: A study was undertaken to test the hypothesis that severe exacerbations of asthma are characterised by increased bronchial mucosal neutrophilia associated with upregulation of neutrophil chemoattractant ligands and their specific cell surface receptors. METHODS: Immunohistology and in situ hybridisation were applied to endobronchial biopsy specimens from three groups: (1) 15 patients admitted to hospital with a severe exacerbation of asthma (E-asthma), (2) 15 with stable asthma (S-asthma) and (3) 15 non-atopic and non-smoker surgical controls (NSC). RESULTS: There were significantly more neutrophils and eosinophils in the epithelium and subepithelium of patients in the E-asthma group (median (range) neutrophils 7 (0-380) and 78 (10-898)/mm2, eosinophils 31 (0-167) and 60 (6-351)/mm2, p


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CRRD Object Information
CRRD ID: 5135243
Created: 2011-07-15
Species: All species
Last Modified: 2011-07-15
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.