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Pan-neurotrophin receptor p75 contributes to neuronal hyperreactivity and airway inflammation in a murine model of experimental asthma.

Authors: Kerzel, S  Path, G  Nockher, WA  Quarcoo, D  Raap, U  Groneberg, DA  Dinh, QT  Fischer, A  Braun, A  Renz, H 
Citation: Kerzel S, etal., Am J Respir Cell Mol Biol. 2003 Feb;28(2):170-8.
Pubmed: (View Article at PubMed) PMID:12540484
DOI: Full-text: DOI:10.1165/rcmb.4811

Bronchial asthma represents a severe chronic inflammatory disease with increasing prevalence. The pathogenesis is characterized by complex neuroimmune dysregulation. Although the immunopathogenesis of the disease has been extensively studied, the nature of neuronal dysfunction still remains poorly understood. Recent data indicate that neurotrophins contribute to airway inflammation, broncho-obstruction and airway hyperresponsiveness. Using an established murine model of allergic bronchial asthma, the contribution of the pan-neurotrophin receptor p75(NTR) was defined. This receptor is expressed both in normal and asthmatic lungs and airways. Analysis of p75(NTR-/-) mice, as well as in vivo blocking of p75(NTR), revealed that airway inflammation is to a large extent dependent upon functional receptor expression. Furthermore, neuronal hyperreactivity depends entirely on this receptor. Based on these data, a novel molecular pathway in the neuroimmune pathogenesis of bronchial asthma could be defined.

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CRRD Object Information
CRRD ID: 5144072
Created: 2011-07-29
Species: All species
Last Modified: 2011-07-29
Status: ACTIVE



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