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Novel polymorphism of the 5-lipoxygenase activating protein (FLAP) promoter gene associated with asthma.

Authors: Koshino, T  Takano, S  Kitani, S  Ohshima, N  Sano, Y  Takaishi, T  Hirai, K  Yamamoto, K  Morita, Y 
Citation: Koshino T, etal., Mol Cell Biol Res Commun. 1999 Jul;2(1):32-5.
Pubmed: (View Article at PubMed) PMID:10527888
DOI: Full-text: DOI:10.1006/mcbr.1999.0147

The human 5-lipoxygenase activating protein (FLAP) gene is one of the key genes involved in the production of the cysteinyl-leukotrienes. We studied novel polymorphism of the FLAP promoter gene and attempted to clarify the relationship between this polymorphism and asthma. We sequenced the FLAP promoter region, containing the -170 to +46-bp sequence from the translational start codon, and found two homozygotes of novel alleles in the polyadenyl region which showed 21 A repeats and 18 A repeats, respectively. The frequency of the 21 A repeats was 52/71 (73.2%) in asthmatics and 39/71 (54.9%) in control subjects. The difference between these frequencies was statistically significant (P = 0.035). This is the first report of FLAP promoter gene polymorphism associated with asthma. Our data suggest that FLAP promoter gene polymorphism might play a crucial role in the pathogenesis of asthma.


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CRRD Object Information
CRRD ID: 5147466
Created: 2011-08-05
Species: All species
Last Modified: 2011-08-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.