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Expression of 5-lipoxygenase and 5-lipoxygenase-activating protein mRNAs in the peripheral blood leukocytes of asthmatics.

Authors: Koshino, T  Takano, S  Houjo, T  Sano, Y  Kudo, K  Kihara, H  Kitani, S  Takaishi, T  Hirai, K  Ito, K  Morita, Y 
Citation: Koshino T, etal., Biochem Biophys Res Commun. 1998 Jun 18;247(2):510-3.
Pubmed: (View Article at PubMed) PMID:9642160

Leukotrienes are a family of arachidonic acid metabolites with potent biological activities such as bronchoconstriction and leukocyte chemotaxis. Recent evidence has demonstrated that the 5-lipoxygenase (5-LO) and 5-lipoxygenase-activating protein (FALP) products of arachidonic acid metabolism, leukotriene C4, D4 and E4, were increased in the serum and the urine of asthmatic patients. Therefore, we examined the expression of 5-LO and FLAP mRNAs in the peripheral blood leukocytes (PBL) of 10 asthmatics and 10 controls. Both 5-LO and FLAP mRNAs of PBL in the asthmatic group were found to be significantly increased compared with those in the control group. These data suggest that up-regulation of 5-LO and FLAP mRNAs might be involved in the increased leukotriene synthesis and play an important role in the pathogenesis of asthma.


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CRRD Object Information
CRRD ID: 5147467
Created: 2011-08-05
Species: All species
Last Modified: 2011-08-05
Status: ACTIVE


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