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Asthma steroid pharmacogenetics: a study strategy to identify replicated treatment responses.

Authors: Weiss, ST  Lake, SL  Silverman, ES  Silverman, EK  Richter, B  Drazen, JM  Tantisira, KG 
Citation: Weiss ST, etal., Proc Am Thorac Soc. 2004;1(4):364-7.
Pubmed: (View Article at PubMed) PMID:16113459
DOI: Full-text: DOI:10.1513/pats.200409-043MS

Asthma treatment with inhaled steroids demonstrates significant between-person variability. Genetic variation could contribute to this response to inhaled glucocorticosteroids. Difficulties in performing genetic association studies are well known. We designed a test and validation strategy to assess steroid pathway candidate genes. One hundred thirty-one single nucleotide polymorphisms in 14 candidate genes in the steroid pathway were genotyped in an 8-week clinical trial of 470 adults with moderate to severe asthma. We then validated our findings in a second population of individuals with childhood asthma in a 4-year clinical trial of inhaled corticosteroids and a third population of adults with asthma. One gene, corticotrophin-releasing hormone receptor 1 (CRHR1, NM_004382), demonstrated multiple single nucleotide polymorphism associations within each of the three populations. The approach of a test and multiple replication populations is a valuable strategy in asthma pharmacogenetics, which can insure valid association findings.

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CRRD Object Information
CRRD ID: 5147488
Created: 2011-08-08
Species: All species
Last Modified: 2011-08-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.