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Evidence for an association of HLA-DRB1*15 and DRB1*09 with leprosy and the impact of DRB1*09 on disease onset in a Chinese Han population.

Authors: Zhang, F  Liu, H  Chen, S  Wang, C  Zhu, C  Zhang, L  Chu, T  Liu, D  Yan, X  Liu, J 
Citation: Zhang F, etal., BMC Med Genet. 2009 Dec 11;10:133.
Pubmed: (View Article at PubMed) PMID:20003324
DOI: Full-text: DOI:10.1186/1471-2350-10-133

BACKGROUND: Human leukocyte antigens (HLAs) have been proposed to modulate the immune response to Mycobacterium leprae. The association of HLA-DRB1 with leprosy has been reported in several populations, but not in a Chinese population. METHODS: The polymerase chain reaction-sequence-specific oligonucleotide probe with Luminex100 (PCR-SSOP-Luminex) method was used to genotype HLA-DRB1 alleles in 305 leprosy patients and 527 healthy control individuals. RESULTS: The HLA-DRB1*15 allele was significantly more prevalent among leprosy patients than healthy controls, whereas the frequency of the HLA-DRB1*09 allele was lower among leprosy patients, especially those with early-onset disease. CONCLUSION: HLA-DRB1 alleles are associated with leprosy susceptibility in a Chinese population. The HLA-DRB1*09 allele was found to be protective exclusively in a subset of early-onset leprosy patients.


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CRRD Object Information
CRRD ID: 5147585
Created: 2011-08-12
Species: All species
Last Modified: 2011-08-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.