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[Expression of substance P receptor mRNA in nasal mucosa of rat in allergic rhinitis model].

Authors: Xue, J  Zhao, H  An, Y  Liang, A  Zhao, C 
Citation: Xue J, etal., Zhonghua Er Bi Yan Hou Ke Za Zhi. 2000 Aug;35(4):247-50.
Pubmed: (View Article at PubMed) PMID:12768696

OBJECTIVE: To study the expression of substance P receptor messenger RNA (SP-R mRNA) in nasal mucosa in allergic rhinitis (AR) rat model.
METHODS: Twenty Wistar rats free of disease were randomly divided into two groups. AR model rats were established through repeated intraperitoneal shot of ovalbumin (OV) and consequently confirmed by local challenge with OV. SP-R mRNA in nasal mucosa, obtained from two groups, were used to do reverse transcriptive polymerase chain reaction (RT-PCR) and Southern blot. beta-actin was used as a standard control through out the whole process.
RESULTS: The results showed definitely that there were positive expression of SP-R mRNA in normal nasal mucosa. This expressions increased significantly (P < 0.05) during nasal allergy.
CONCLUSION: Increased expression SP-R mRNA in nasal mucosa in AR model might play roles in the development of AR.


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CRRD Object Information
CRRD ID: 5147835
Created: 2011-08-23
Species: All species
Last Modified: 2011-08-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.