Experimental autoimmune encephalomyelitis (EAE) IN C57Bl/6 mice is not associated with astrogliosis.

Authors: Pham, H  Doerrbecker, J  Ramp, AA  D'Souza, CS  Gorasia, DG  Purcell, AW  Ayers, MM  Orian, JM 
Citation: Pham H, etal., J Neuroimmunol. 2011 Mar;232(1-2):51-62. Epub 2010 Nov 6.
Pubmed: (View Article at PubMed) PMID:21056916
DOI: Full-text: DOI:10.1016/j.jneuroim.2010.10.006

The C57Bl/6 mouse is the preferred host for the maintenance of gene deletion mutants and holds a unique place in investigations of cytokine/chemokine networks in neuroinflammation. It is also susceptible to experimental autoimmune encephalomyelitis (EAE), a multiple sclerosis (MS)-like disease commonly used to assess potential MS therapies. Investigations of glial reactivity in EAE have revealed hitherto undescribed astroglial responses in this model, characterized by progressively diminishing glial fibrillary acidic protein and aquaporin-4 immunostaining, from early disease. These observations show that astrocyte responses vary with the EAE paradigm and are an important pathological criterion for disease mapping and therapy evaluation.


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CRRD Object Information
CRRD ID: 5148015
Created: 2011-09-01
Species: All species
Last Modified: 2011-09-01
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.