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Investigation of an LDLR gene polymorphism (19p13.2) in susceptibility to migraine without aura.

Authors: Mochi, M  Cevoli, S  Cortelli, P  Pierangeli, G  Scapoli, C  Soriani, S  Montagna, P 
Citation: Mochi M, etal., J Neurol Sci. 2003 Sep 15;213(1-2):7-10.
Pubmed: (View Article at PubMed) PMID:12873747

We performed a genetic association study with the LDL receptor gene (LDLR) on chromosome 19p13.2 in 360 migraine patients, 220 with migraine without aura (MO) and 140 with migraine with aura (MA), and 200 controls, by analysing two polymorphic markers, a G142A transition in exon 10 and a triallelic (TA)n repeat in exon 18. The allelic distribution of the (TA)n polymorphism was significantly different between migraine without aura (MO) and both controls and migraine with aura (MA). We suggest a possible predisposition to MO in the studied population through this polymorphism or another polymorphism in linkage disequilibrium with (TA)n.


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CRRD Object Information
CRRD ID: 5490245
Created: 2011-09-09
Species: All species
Last Modified: 2011-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.