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Association of the glutathione S-transferase M1 homozygous null genotype with susceptibility to Sjogren's syndrome in Japanese individuals.

Authors: Morinobu, A  Kanagawa, S  Koshiba, M  Sugai, S  Kumagai, S 
Citation: Morinobu A, etal., Arthritis Rheum. 1999 Dec;42(12):2612-5.
Pubmed: (View Article at PubMed) PMID:10616008
DOI: Full-text: DOI:10.1002/1529-0131(199912)42:12<2612::AID-ANR15>3.0.CO;2-V

OBJECTIVE: To investigate the role of polymorphisms of the glutathione S-transferase M1 (GSTM1) and GSTT1 genes in determining susceptibility to Sjogren's syndrome (SS) and autoantibody production. METHODS: Polymorphisms of the GSTM1 and GSTT1 genes in 106 Japanese patients with primary SS and in 143 healthy controls were analyzed by polymerase chain reaction. RESULTS: Frequency of the GSTM1 homozygous null genotype was significantly increased in SS patients compared with controls (57.5% versus 44.1%; P = 0.035). Moreover, a significantly greater frequency of SSA antibodies was found among SS patients with the GSTM1 null genotype than among those with the GSTM1 non-null genotype (P = 0.0013). Frequency of the GSTT1 polymorphism was not different between SS patients and controls. CONCLUSION: The GSTM1 homozygous null genotype could be a genetic factor that determines susceptibility to SS and may be involved in SSA antibody production.


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CRRD Object Information
CRRD ID: 5491001
Created: 2011-09-26
Species: All species
Last Modified: 2011-09-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.