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Gene expression profile of amyloid beta protein-injected mouse model for Alzheimer disease.

Authors: Kong, LN  Zuo, PP  Mu, L  Liu, YY  Yang, N 
Citation: Kong LN, etal., Acta Pharmacol Sin. 2005 Jun;26(6):666-72.
Pubmed: (View Article at PubMed) PMID:15916731
DOI: Full-text: DOI:10.1111/j.1745-7254.2005.00129.x

AIM: To investigate the gene expression profile changes in the cerebral cortex of mice injected icv with amyloid beta-protein (Abeta) fragment 25-35 using cDNA microarray. METHODS: Balb/c mice were randomly divided into a control group and Abeta-treated group. The Morris water maze test was performed to detect the effect of Abeta-injection on the learning and memory of mice. Atlas Mouse 1.2 Expression Arrays containing 1176 genes were used to investigate the gene expression pattern of each group. RESULTS: The gene expression profiles showed that 19 genes including TBX1, NF-kB, AP-1/c-Jun, cadherin, integrin, erb-B2, and FGFR1 were up-regulated after 2 weeks of icv administration of Abeta; while 12 genes were down-regulated, including NGF, glucose phosphate isomerase 1, AT motif binding factor 1, Na+/K+-ATPase, and Akt. CONCLUSIONS: The results provide important leads for pursuing a more complete understanding of the molecular events of Abeta-injection into mice with Alzheimer disease.


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CRRD Object Information
CRRD ID: 5508772
Created: 2011-10-21
Species: All species
Last Modified: 2011-10-21
Status: ACTIVE


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