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Apolipoprotein A-IV is a candidate target molecule for the treatment of seasonal allergic rhinitis.

Authors: Makino, Y  Noguchi, E  Takahashi, N  Matsumoto, Y  Kubo, S  Yamada, T  Imoto, Y  Ito, Y  Osawa, Y  Shibasaki, M  Uchida, K  Meno, K  Suzuki, H  Okubo, K  Arinami, T  Fujieda, S 
Citation: Makino Y, etal., J Allergy Clin Immunol. 2010 Dec;126(6):1163-9.e5.
Pubmed: (View Article at PubMed) PMID:20810159
DOI: Full-text: DOI:10.1016/j.jaci.2010.06.031

BACKGROUND: Allergic rhinitis is a global health problem that causes major illnesses and disability worldwide. Allergen-specific immunotherapy (SIT) is the only available treatment that can alter the natural course of allergic disease. However, the precise mechanism underlying allergen-SIT is not well understood. OBJECTIVE: The aim of the current study was to identify protein expression signatures reflective of allergen-SIT-more specifically, sublingual immunotherapy (SLIT). METHODS: Serum was taken twice from patients with seasonal allergic rhinitis caused by Japanese cedar: once before the pollen season and once during the season. A total of 25 patients was randomly categorized into a placebo-treated group and an active-treatment group. Their serum protein profiles were analyzed by 2-dimensional electrophoresis. RESULTS: Sixteen proteins were found to be differentially expressed during the pollen season. Among the differentially expressed proteins, the serum levels of complement C4A, apolipoprotein A-IV (apoA-IV), and transthyretin were significantly increased in SLIT-treated patients but not in placebo-treated patients. Among these proteins, the serum levels of apoA-IV correlated with the clinical symptom-medication scores (r = -0.635; P < .05) and with quality of life scores (r = -0.516; P < .05) in the case of SLIT-treated patients. The amount of histamine released from the basophils in vitro was greatly reduced after the addition of recombinant apoA-IV in the medium (P < .01). CONCLUSION: Our data will increase the understanding of the mechanism of SLIT and may provide novel insights into the treatment of allergic rhinitis.

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CRRD Object Information
CRRD ID: 5685642
Created: 2012-01-13
Species: All species
Last Modified: 2012-01-13
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.