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Patients with active relapsing-remitting multiple sclerosis synthesize antibodies recognizing oligodendrocyte progenitor cell surface protein: implications for remyelination.

Authors: Niehaus, A  Shi, J  Grzenkowski, M  Diers-Fenger, M  Archelos, J  Hartung, HP  Toyka, K  Bruck, W  Trotter, J 
Citation: Niehaus A, etal., Ann Neurol. 2000 Sep;48(3):362-71.
Pubmed: (View Article at PubMed) PMID:10976643

In multiple sclerosis (MS), remyelination of demyelinated lesions diminishes with disease progression for unknown reasons. Oligodendrocyte progenitor cells contribute to remyelination; however, antibodies specific for oligodendrocyte progenitor antigens could block remyelination by eliminating or impeding these cells. In myelinating cultures, cell lysis with antibody recognizing a progenitor cell-specific surface glycoprotein (AN2) suppressed the synthesis of myelin proteins. Cerebrospinal fluid from patients with relapsing-remitting active MS contains antibodies against AN2, whereas cerebrospinal fluid from patients with nonactive disease does not. This is the first report describing antibodies in MS against a progenitor cell-specific antigen that may contribute to the development and progression of chronically demyelinated lesions.


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CRRD Object Information
CRRD ID: 5686865
Created: 2012-01-27
Species: All species
Last Modified: 2012-01-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.