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Tiarellic acid attenuates airway hyperresponsiveness and inflammation in a murine model of allergic asthma.

Authors: Lee, MY  Ahn, KS  Lim, HS  Yuk, JE  Kwon, OK  Lee, KY  Lee, HK  Oh, SR 
Citation: Lee MY, etal., Int Immunopharmacol. 2012 Jan;12(1):117-24. Epub 2011 Nov 12.
Pubmed: (View Article at PubMed) PMID:22085848
DOI: Full-text: DOI:10.1016/j.intimp.2011.10.021

Asthma is a persistent inflammatory disease characterized by airway obstruction and hyperresponsiveness in association with airway inflammation. In the current research, we studied the anti-inflammatory and anti-asthmatic effects of tiarellic acid (TA) isolated from Tiarella polyphylla, based on asthmatic parameters, such as immunoglobulin E (IgE) level, cytokine release, eosinophilia, airway hyperresponsiveness (AHR), reactive oxygen species (ROS) and mucus hypersecretion, in an ovalbumin (OVA)-sensitized/challenged mouse model. TA significantly inhibited increases in IgE, levels of ROS and T helper cytokines, such as interleukin (IL)-4, IL-5, TNF-alpha, and IL-13, in bronchoalveolar lavage fluid (BALF), and effectively suppressed airway hyperresponsiveness, eosinophilia, and mucus hypersecretion in the asthmatic mouse model. In addition, we found that administration of TA attenuated ovalbumin-induced increases in NF-kappaB activity in lungs. The efficacy of TA was comparable to that of montelukast, a currently available anti-asthmatic drug. Our results support the utility of TA as a herbal medicine for asthma treatment and may have application in the development of anti-inflammatory and anti-asthmatic drugs.


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CRRD Object Information
CRRD ID: 5687144
Created: 2012-02-01
Species: All species
Last Modified: 2012-02-01
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.