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The CD26-related dipeptidyl aminopeptidase-like protein DPPX is a critical component of neuronal A-type K+ channels.

Authors: Nadal, MS  Ozaita, A  Amarillo, Y  Vega-Saenz de Miera, E  Ma, Y  Mo, W  Goldberg, EM  Misumi, Y  Ikehara, Y  Neubert, TA  Rudy, B 
Citation: Nadal MS, etal., Neuron. 2003 Feb 6;37(3):449-61.
Pubmed: (View Article at PubMed) PMID:12575952

Subthreshold-activating somatodendritic A-type potassium channels have fundamental roles in neuronal signaling and plasticity which depend on their unique cellular localization, voltage dependence, and kinetic properties. Some of the components of A-type K(+) channels have been identified; however, these do not reproduce the properties of the native channels, indicating that key molecular factors have yet to be unveiled. We purified A-type K(+) channel complexes from rat brain membranes and found that DPPX, a protein of unknown function that is structurally related to the dipeptidyl aminopeptidase and cell adhesion protein CD26, is a novel component of A-type K(+) channels. DPPX associates with the channels' pore-forming subunits, facilitates their trafficking and membrane targeting, reconstitutes the properties of the native channels in heterologous expression systems, and is coexpressed with the pore-forming subunits in the somatodendritic compartment of CNS neurons.


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CRRD Object Information
CRRD ID: 5687190
Created: 2012-02-03
Species: All species
Last Modified: 2012-02-03
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.