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Regeneration-enhancing effects of EphA4 blocking peptide following corticospinal tract injury in adult rat spinal cord.

Authors: Fabes, J  Anderson, P  Brennan, C  Bolsover, S 
Citation: Fabes J, etal., Eur J Neurosci. 2007 Nov;26(9):2496-505. Epub 2007 Oct 26.
Pubmed: (View Article at PubMed) PMID:17970742
DOI: Full-text: DOI:10.1111/j.1460-9568.2007.05859.x

Spinal cord injury often leads to permanent incapacity because long axons cannot regenerate in the CNS. Eph receptors inhibit axon extension through an effect on the actin cytoskeleton. We have previously reported that after injury EphA4 appears at high levels in stumps of corticospinal axons, while a cognate ligand, ephrinB2, is upregulated at the lesion site so as to confine the injured axons. In this study we have infused lesioned spinal cords with a peptide antagonist of EphA4. In treated animals the retrograde degeneration that normally follows corticospinal tract injury is absent. Rather, corticospinal tract axons sprout up to and into the lesion centre. In a behavioural test of corticospinal tract function, peptide treatment substantially improved recovery relative to controls. These results suggest that blocking EphA4 is likely to contribute to a future successful clinical treatment for spinal cord injury.


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CRRD Object Information
CRRD ID: 5688750
Created: 2012-03-05
Species: All species
Last Modified: 2012-03-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.