Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat

Authors: Galli, J  Li, LS  Glaser, A  Ostenson, CG  Jiao, H  Fakhrai-Rad, H  Jacob, HJ  Lander, ES  Luthman, H 
Citation: Galli J, etal., Nat Genet 1996 Jan;12(1):31-7
Pubmed: (View Article at PubMed) PMID:8528247
DOI: Full-text: DOI:10.1038/ng0196-31

Non-insulin dependent diabetes mellitus (NIDDM) is a major public health problem, but its aetiology remains poorly understood. We have performed a comprehensive study of the genetic basis of diabetes in the Goto-Kakizaki (GK) rat, the most widely used animal model of non-obese NIDDM. The genetic dissection of NIDDM using this model has allowed us to map three independent loci involved in the disease. In addition, we identify a major factor affecting body weight, but not glucose tolerance, on chromosome 7 and map a further 10 regions that are suggestive for linkage. We conclude that NIDDM is polygenic and fasting hyperglycaemia and postprandial hyperglycaemia clearly have distinct genetic bases.


Disease Annotations
Phenotype Annotations
Experimental Data Annotations
Objects Annotated
Objects referenced in this article

Additional Information

CRRD Object Information
CRRD ID: 61082
Created: 2000-12-21
Species: All species
Last Modified: 2003-08-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.