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Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat.

Authors: Szpirer, C  Van Vooren, P  Riviere, M  Cohy S, S  Collau, G  Szpirer, J 
Citation: Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35
Web Url: http://link.springer.de/link/service/journals/00335/bibs/0011009/00110729. htm
Pubmed: (View Article at PubMed) PMID:10967130

In order to improve the rat gene map and comparative mapping with the human and the mouse, we determined the chromosome localization of 54 rat genes. Most genes encode transcription factors or other regulatory proteins of cancer relevance. The human homologs of four genes were also assigned to their respective chromosome. These data generated anchor points between the recently established radiation hybrid maps and the genetic and cytogenetic maps. They improve comparative mapping between the rat, the mouse, and the human gene maps, and in particular they disclose four new synteny groups conserved in the rat and the human. These new localizations should also be useful for the identification of genes involved in the control of quantitative traits such as cancer susceptibility or diabetes.

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CRRD Object Information
CRRD ID: 61490
Created: 2001-01-29
Species: All species
Last Modified: 2001-01-29
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.