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G-protein gamma 7 subunit is selectively expressed in medium-sized neurons and dendrites of the rat neostriatum.

Authors: Watson, JB  Coulter, PM  Margulies, JE  De Lecea, L  Danielson, PE  Erlander, MG  Sutcliffe, JG 
Citation: Watson JB, etal., J Neurosci Res 1994 Sep 1;39(1):108-16.
Pubmed: (View Article at PubMed) PMID:7807587
DOI: Full-text: DOI:10.1002/jnr.490390113

We used subtractive hybridization to isolate clones of gamma 7, a 68 residue G-protein gamma subunit. Northern blotting and in situ hybridization reveal that the gamma 7 subunit mRNA is expressed primarily in medium-sized neurons of the neostriatum and nucleus accumbens and neurons of the olfactory tubercle, and at low levels in the dentate gyrus of the hippocampal formation and laminae II-III, and V of the neocortex. The gamma 7 mRNA is translocated into dendrites of neurons in the neostriatum and the dentate gyrus of the hippocampus. gamma 7 is expressed at relatively very low concentrations in peripheral tissues. The selective pattern of gamma 7 expression within the brain is highly reminiscent of those of the striatum-enriched adenylyl cyclase ACST, dopamine receptors, and the alpha subunit of G(olf), suggesting that, in striatum, gamma 7 may be a subunit of a G(olf) alpha-containing G protein that couples dopamine receptors selectively to ACST.


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CRRD Object Information
CRRD ID: 61610
Created: 2001-04-10
Species: All species
Last Modified: 2001-04-10
Status: ACTIVE


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