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Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors.

Authors: Kidd, T  Brose, K  Mitchell, KJ  Fetter, RD  Tessier-Lavigne, M  Goodman, CS  Tear, G 
Citation: Kidd T, etal., Cell 1998 Jan 23;92(2):205-15.
Pubmed: (View Article at PubMed) PMID:9458045

The robo gene in Drosophila was identified in a large-scale mutant screen for genes that control the decision by axons to cross the CNS midline. In robo mutants, too many axons cross and recross the midline. Here we show that robo encodes an axon guidance receptor that defines a novel subfamily of immunoglobulin superfamily proteins that is highly conserved from fruit flies to mammals. For those axons that never cross the midline, Robo is expressed on their growth cones from the outset; for the majority of axons that do cross the midline, Robo is expressed at high levels on their growth cones only after they cross the midline. Transgenic rescue experiments reveal that Robo can function in a cell-autonomous fashion. Robo appears to function as the gatekeeper controlling midline crossing.


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CRRD Object Information
CRRD ID: 61733
Created: 2001-04-10
Species: All species
Last Modified: 2001-04-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.