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Discordant expression of c-Ret and glial cell line-derived neurotrophic factor receptor alpha-1 mRNAs in response to motor nerve injury in neonate rats.

Authors: Tsujino, H  Mansur, K  Kiryu-Seo, S  Namikawa, K  Kitahara, T  Tanabe, K  Ochi, T  Kiyama, H 
Citation: Tsujino H, etal., Brain Res Mol Brain Res. 1999 Jul 5;70(2):298-303.
Pubmed: (View Article at PubMed) PMID:10407179

Adult motoneurons can survive following axotomy, whereas neonate motoneurons result in cell death. Following hypoglossal nerve axotomy in neonate rat, Glial cell line-Derived Neurotrophic Factor (GDNF) receptor alpha-1 (GFRalpha-1) mRNA expression was dramatically suppressed in the injured motoneurons, while a slight increase of c-Ret mRNA expression was observed. In adult, both GFRalpha-1 and c-Ret mRNAs increased substantially after axotomy. The present result suggests that the difference of motoneuron fate after axotomy may be partly due to the coordinate or discordant responses of GFRalpha-1 and c-Ret expression to nerve injury.


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CRRD Object Information
CRRD ID: 6218979
Created: 2012-03-07
Species: All species
Last Modified: 2012-03-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.