Dystrophin-glycoprotein complex and Ras and Rho GTPase signaling are altered in muscle atrophy.

Authors: Chockalingam, PS  Cholera, R  Oak, SA  Zheng, Y  Jarrett, HW  Thomason, DB 
Citation: Chockalingam PS, etal., Am J Physiol Cell Physiol 2002 Aug;283(2):C500-11.
Pubmed: (View Article at PubMed) PMID:12107060
DOI: Full-text: DOI:10.1152/ajpcell.00529.2001

The dystrophin-glycoprotein complex (DGC) is a sarcolemmal complex whose defects cause muscular dystrophies. The normal function of this complex is not clear. We have proposed that this is a signal transduction complex, signaling normal interactions with matrix laminin, and that the response is normal growth and homeostasis. If so, the complex and its signaling should be altered in other physiological states such as atrophy. The amount of some of the DGC proteins, including dystrophin, beta-dystroglycan, and alpha-sarcoglycan, is reduced significantly in rat skeletal muscle atrophy induced by tenotomy. Furthermore, H-Ras, RhoA, and Cdc42 decrease in expression levels and activities in muscle atrophy. When the small GTPases were assayed after laminin or beta-dystroglycan depletion, H-Ras, Rac1, and Cdc42 activities were reduced, suggesting a physical linkage between the DGC and the GTPases. Dominant-negative Cdc42, introduced with a retroviral vector, resulted in fibers that appeared atrophic. These data support a putative role for the DGC in transduction of mechanical signals in muscle.


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CRRD Object Information
CRRD ID: 625642
Created: 2002-10-18
Species: All species
Last Modified: 2002-10-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.