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Effect of annexin I on insulin secretion through surface binding sites in rat pancreatic islets.

Authors: Hong, SH  Won, JH  Yoo, SA  Auh, CK  Park, YM 
Citation: Hong SH, etal., FEBS Lett 2002 Dec 4;532(1-2):17-20.
Pubmed: (View Article at PubMed) PMID:12459455

This study investigates the effect of extracellular annexin I (Anx I) on regulating insulin secretion in isolated rat pancreatic islets. Results show that Anx I stimulates insulin release in pancreatic islets regardless of the presence or absence of extracellular Ca(2+). In particular, confocal microscopy shows that Anx I binds to the surface of islet cells in the absence of extracellular Ca(2+). However, insulin secretion through Anx I significantly decreases in trypsin-treated islets. Likewise, there is minimal binding of Anx I to the surface of trypsin-treated islets. Anti-Anx I polyclonal antibody also inhibits the stimulating effect of Anx I on insulin secretion. These results indicate that Anx I is capable of binding to the cell surface receptor, in order to regulate the stimulation of insulin release in rat pancreatic islets.


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CRRD Object Information
CRRD ID: 628365
Created: 2002-12-13
Species: All species
Last Modified: 2002-12-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.