AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis.

Authors: Page, G  Lodige, I  Kogel, D  Scheidtmann, KH 
Citation: Page G, etal., FEBS Lett 1999 Nov 26;462(1-2):187-91.
Pubmed: (View Article at PubMed) PMID:10580117

Dlk, also known as ZIP kinase, is a serine/threonine kinase that is tightly associated with nuclear structures. Under certain conditions, which require cytoplasmic localization, Dlk can induce apoptosis. In search for interaction partners that might serve as regulators or targets of this kinase we identified apoptosis antagonizing transcription factor (AATF), a nuclear phosphoprotein of 523 amino acids. The 1.8 kb mRNA seems to be ubiquitously expressed. AATF contains an extremely acidic domain and a putative leucine zipper characteristic of transcription factors. Indeed, a Gal4-BD-AATF fusion protein exhibited strong transactivation activity. Interestingly, AATF interfered with Dlk-induced apoptosis.


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CRRD Object Information
CRRD ID: 631947
Created: 2003-08-21
Species: All species
Last Modified: 2003-08-21
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.