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Expression of a functional IL-13Ralpha1 by rat B cells.

Authors: Pierrot, C  Beniguel, L  Begue, A  Khalife, J 
Citation: Pierrot C, etal., Biochem Biophys Res Commun 2001 Oct 5;287(4):969-76.
Pubmed: (View Article at PubMed) PMID:11573960
DOI: Full-text: DOI:10.1006/bbrc.2001.5682

IL-13 mediates its effects through a complex receptor system including IL-4Ralpha and a functional IL-13Ralpha1. IL-13 has been reported to have no effects on mouse B cells due to a lack of receptor expression. However, on human B cells a functional IL-13Ralpha1 has been described. Here, we identified the rat IL-13Ralpha1 in order to analyze its expression and function in rat B cells. The expression of IL-13Ralpha1 has been shown by the presence of mRNA and the corresponding protein in purified rat B cells and in rat hybridoma B cell line. Rat B cells are able to bind IL-13 and to proliferate when cultured with CD40 ligand and IL-13. In vivo experiments showed that administration of IL-13 did enhance IgE production. These results suggest a direct interaction of rat B cells with IL-13 through a functional receptor with an increase of IgE production and provide a relevant model to further study the activity of IL-13 and to better understand its role in human diseases.


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CRRD Object Information
CRRD ID: 633067
Created: 2003-08-29
Species: All species
Last Modified: 2004-05-25
Status: ACTIVE


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