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An orphan nuclear receptor lacking a zinc-finger DNA-binding domain: interaction with several nuclear receptors.

Authors: Masuda, N  Yasumo, H  Tamura, T  Hashiguchi, N  Furusawa, T  Tsukamoto, T  Sadano, H  Osumi, T 
Citation: Masuda N, etal., Biochim Biophys Acta 1997 Jan 3;1350(1):27-32.
Pubmed: (View Article at PubMed) PMID:9003453

The yeast two-hybrid screening was applied to cloning cDNAs of proteins that interact with peroxisome proliferator-activated receptor alpha (PPAR alpha). We obtained from a rat liver cDNA library a clone encoding a protein related to the ligand-binding domain of the members of nuclear hormone receptor superfamily, whereas apparently lacking the zinc-finger DNA-binding domain. This protein interacted with the activated forms of several nuclear receptors, and thus is a novel type of heterodimer-forming nuclear receptor.


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CRRD Object Information
CRRD ID: 633448
Created: 2003-08-29
Species: All species
Last Modified: 2004-05-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.