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Neuropeptide Y-Y2 receptors mediate anxiety in the amygdala.

Authors: Sajdyk, TJ  Schober, DA  Smiley, DL  Gehlert, DR 
Citation: Sajdyk TJ, etal., Pharmacol Biochem Behav 2002 Mar;71(3):419-23.
Pubmed: (View Article at PubMed) PMID:11830176

The behavioral effects of direct injection of the neuropeptide Y (NPY) Y2 receptor agonist C2-NPY into the basolateral nucleus of the amygdala (BLA) was assessed in rats utilizing the social interaction test (SI). C2-NPY decreased SI time in a dose-dependent manner with a significant change observed at a dose of 80 pmol/100 nl. The anxiogenic effects produced by intra-amygdalar C2-NPY injections were reversed with intraperitoneal administration of alprazolam (1 mg/kg), a known anxiolytic. These findings support the hypothesis that Y2 receptors are involved in the regulation of the anxiety response.


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CRRD Object Information
CRRD ID: 633496
Created: 2003-08-29
Species: All species
Last Modified: 2004-05-25
Status: ACTIVE


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