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KID-1, a protein kinase induced by depolarization in brain.

Authors: Feldman, JD  Vician, L  Crispino, M  Tocco, G  Marcheselli, VL  Bazan, NG  Baudry, M  Herschman, HR 
Citation: Feldman JD, etal., J Biol Chem 1998 Jun 26;273(26):16535-43.
Pubmed: (View Article at PubMed) PMID:9632723

Membrane depolarization leads to changes in gene expression that modulate neuronal plasticity. Using representational difference analysis, we have identified a previously undiscovered cDNA, KID-1 (kinase induced by depolarization), that is induced by membrane depolarization or forskolin, but not by neurotrophins or growth factors, in PC12 pheochromocytoma cells. KID-1 is an immediate early gene that shares a high degree of sequence similarity with the family of PIM-1 serine/threonine protein kinases. Recombinant KID-1 fusion protein is able to catalyze both histone phosphorylation and autophosphorylation. KID-1 mRNA is present in a number of unstimulated tissues, including brain. In response to kainic acid and electroconvulsive shock-induced seizures, KID-1 is induced in specific regions of the hippocampus and cortex.


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CRRD Object Information
CRRD ID: 633695
Created: 2003-08-29
Species: All species
Last Modified: 2004-05-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.