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TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator.

Authors: Migone, TS  Zhang, J  Luo, X  Zhuang, L  Chen, C  Hu, B  Hong, JS  Perry, JW  Chen, SF  Zhou, JX  Cho, YH  Ullrich, S  Kanakaraj, P  Carrell, J  Boyd, E  Olsen, HS  Hu, G  Pukac, L  Liu, D  Ni, J  Kim, S  Gentz, R  Feng, P  Moore, PA  Ruben, SM  Wei, P 
Citation: Migone TS, etal., Immunity 2002 Mar;16(3):479-92.
Pubmed: (View Article at PubMed) PMID:11911831

DR3 is a death domain-containing receptor that is upregulated during T cell activation and whose overexpression induces apoptosis and NF-kappaB activation in cell lines. Here we show that an endothelial cell-derived TNF-like factor, TL1A, is a ligand for DR3 and decoy receptor TR6/DcR3 and that its expression is inducible by TNF and IL-1alpha. TL1A induces NF-kappaB activation and apoptosis in DR3-expressing cell lines, while TR6-Fc protein antagonizes these signaling events. Interestingly, in T cells, TL1A acts as a costimulator that increases IL-2 responsiveness and secretion of proinflammatory cytokines both in vitro and in vivo. Our data suggest that interaction of TL1A with DR3 promotes T cell expansion during an immune response, whereas TR6 has an opposing effect.


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CRRD Object Information
CRRD ID: 634236
Created: 2003-08-29
Species: All species
Last Modified: 2003-08-29
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.