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Prolactin induces switching of T-cell receptor gene expression from alpha to gamma in rat Nb2 pre-T lymphoma cells(1)

Authors: Hosokawa, Y  Yang, M  Kaneko, S  Tanaka, M  Nakashima, K 
Citation: Hosokawa Y, etal., Biochem Biophys Res Commun 1996 Mar 27;220(3):958-62.
Pubmed: (View Article at PubMed) PMID:8607875

Prolactin (PRL) is considered to be an immunomodulator. This study was conducted to analyze the actions of PRL on the gene expressions for T-cell receptor (TCR) chains in a fat pre-T lymphoma cell line, Nb2. PRL remarkably stimulated the gene expression for TCR gamma chain within 4 h and suppressed TCR alpha chain mRNA expression within 8 h in Nb2 cells. The expression of TCR beta mRNA in the cells was concomitantly, but to a less extent, repressed by the hormone treatment. These results suggest that PRL may participate in the regulation of mammalian T-cell differentiation and development.


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CRRD Object Information
CRRD ID: 634395
Created: 2003-08-29
Species: All species
Last Modified: 2006-04-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.