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The rat beta 1-subunit of the GABAA receptor forms a picrotoxin-sensitive anion channel open in the absence of GABA.

Authors: Sigel, E  Baur, R  Malherbe, P  Mohler, H 
Citation: Sigel E, etal., FEBS Lett. 1989 Nov 6;257(2):377-9.
Pubmed: (View Article at PubMed) PMID:2479580

The structural basis of GABA-gated chloride channels in mammalian brain is presently explored by the functional expression of cDNAs coding for the alpha, beta or gamma-subunits of the receptor and their isoforms. In this context, we expressed the cloned cDNA coding for the rat beta 1-subunit of the GABAA receptor in the Xenopus oocyte. Surprisingly, efficient expression of a functional ion channel was found. The channel was anion-selective, and able to open in the absence of GABA. Since this channel could be shunt by the GABA-channel blocker picrotoxin, we conclude that the beta 1-subunit of the GABAA receptor is sufficient to form binding sites for picrotoxin.


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CRRD Object Information
CRRD ID: 6480230
Created: 2012-03-19
Species: All species
Last Modified: 2012-03-19
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.