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mRNA and protein levels for GABAAalpha4, alpha5, beta1 and GABABR1 receptors are altered in brains from subjects with autism.

Authors: Fatemi, SH  Reutiman, TJ  Folsom, TD  Rooney, RJ  Patel, DH  Thuras, PD 
Citation: Fatemi SH, etal., J Autism Dev Disord. 2010 Jun;40(6):743-50.
Pubmed: (View Article at PubMed) PMID:20066485
DOI: Full-text: DOI:10.1007/s10803-009-0924-z

We have shown altered expression of gamma-aminobutyric acid A (GABA(A)) and gamma-aminobutyric acid B (GABA(B)) receptors in the brains of subjects with autism. In the current study, we sought to verify our western blotting data for GABBR1 via qRT-PCR and to expand our previous work to measure mRNA and protein levels of 3 GABA(A) subunits previously associated with autism (GABRalpha4; GABRalpha5; GABRbeta1). Three GABA receptor subunits demonstrated mRNA and protein level concordance in superior frontal cortex (GABRalpha4, GABRalpha5, GABRbeta1) and one demonstrated concordance in cerebellum (GABBetaR1). These results provide further evidence of impairment of GABAergic signaling in autism.


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CRRD Object Information
CRRD ID: 6480253
Created: 2012-03-20
Species: All species
Last Modified: 2012-03-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.