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Association of TAP 1 and 2 gene polymorphisms with human immunodeficiency virus-tuberculosis co-infection.

Authors: Sunder, SR  Hanumanth, SR  Gaddam, S  Jonnalagada, S  Valluri, VL 
Citation: Sunder SR, etal., Hum Immunol. 2011 Oct;72(10):908-11. Epub 2011 Jul 31.
Pubmed: (View Article at PubMed) PMID:21843574
DOI: Full-text: DOI:10.1016/j.humimm.2011.07.304

Major histocompatibility complex (MHC) class I binding peptides are carried from cytosol to the lumen of the endoplasmic reticulum (ER) by transporter associated with antigen processing (TAP), an integral ER membrane protein composed of two subunits, TAP1 and TAP2. Polymorphism in TAP genes may influence these proteins further affecting the antigen peptide presentation, indirectly resulting in the viral escape mechanism from cell-mediated immunity in human immunodeficiency virus (HIV). Our aim was to study the influence of these polymorphism in study groups with HIV-tuberculosis (TB) (n = 110), TB (n = 105), and HIV (n = 130) compared with healthy controls (n = 183), using the tetraprimer amplification refractory mutation system (ARMS)-polymerase chain reaction method. Our results demonstrated that the GG genotype at TAP1 position 333 and GA genotype at TAP1 position 637 were positively associated with HIV-TB co-infection and these genotypes may act as a risk factor for developing TB co-infection in HIV-positive individuals.


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CRRD Object Information
CRRD ID: 6482248
Created: 2012-04-20
Species: All species
Last Modified: 2012-04-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.