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A TAP2 genotype associated with Alzheimer's disease in APOE4 carriers.

Authors: Bullido, MJ  Martinez-Garcia, A  Artiga, MJ  Aldudo, J  Sastre, I  Gil, P  Coria, F  Munoz, DG  Hachinski, V  Frank, A  Valdivieso, F 
Citation: Bullido MJ, etal., Neurobiol Aging. 2007 Apr;28(4):519-23. Epub 2006 Apr 3.
Pubmed: (View Article at PubMed) PMID:16595160
DOI: Full-text: DOI:10.1016/j.neurobiolaging.2006.02.011

Sporadic Alzheimer's disease (AD) appears to be the consequence of the interaction between combinations of genes and environmental factors. Binding with the transporter associated with antigen processing (TAP) is thought to be the main way in which herpes simplex virus type 1 (HSV-1) evades immune surveillance. Several TAP gene polymorphisms were examined and a TAP2 SNP (rs241448) associated with AD found in two independent case-control samples, especially in carriers of the APOE4 allele. These findings are consistent with the hypothesis that human genetic variants facilitating the access of HSV-1 to the brain might result in susceptibility to AD.


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CRRD Object Information
CRRD ID: 6482265
Created: 2012-04-23
Species: All species
Last Modified: 2012-04-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.