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L1 is associated with micrometastatic spread and poor outcome in colorectal cancer.

Authors: Kaifi, JT  Reichelt, U  Quaas, A  Schurr, PG  Wachowiak, R  Yekebas, EF  Strate, T  Schneider, C  Pantel, K  Schachner, M  Sauter, G  Izbicki, JR 
Citation: Kaifi JT, etal., Mod Pathol. 2007 Nov;20(11):1183-90. Epub 2007 Sep 14.
Pubmed: (View Article at PubMed) PMID:17873897
DOI: Full-text: DOI:10.1038/modpathol.3800955

L1 is a cell adhesion molecule expressed at the invasive front of colorectal tumors with an important role in metastasis. The aim of the present study was to determine L1 protein expression in a large cohort of colorectal cancer patients and its impact on early metastatic spread and survival. A total of 375 patients that underwent surgical treatment for colorectal cancer were chosen retrospectively. A tissue microarray was constructed of 576 tissue samples from these patients and analyzed by immunohistochemistry with a monoclonal antibody against human L1 (UJ127). Lymph node and bone marrow micrometastasis were assessed with monoclonal antibodies Ber-EP4 and pancytokeratin A45-B/B3, respectively. Associations between L1 expression and lymph node, bone marrow micrometastasis and survival were investigated with Fisher's, log-rank test and Cox multivariate analysis. All statistical tests were two-sided. L1 was detected in a subset of 48 (13%) of 375 patients examined. Analysis of L1 expression and survival revealed a significantly worse outcome for L1-positive patients by log-rank test (P<0.05). Multivariate Cox regression analysis showed the strongest independent prognostic impact of L1 expression (P<0.05). Fisher's test revealed a significant association of L1 expression and presence of disseminated tumor cells in lymph nodes and bone marrow (P<0.05). L1 is a powerful prognostic marker for patients that undergo complete surgical resection. It may have a role in early metastatic spread, as L1 is associated with micrometastases to both the lymph nodes and bone marrow. Thus, L1 should be explored further as a target for adjuvant therapy for micrometastatic disease.

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CRRD Object Information
CRRD ID: 6483011
Created: 2012-05-09
Species: All species
Last Modified: 2012-05-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.