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Crosstalk between platelet-derived growth factor-induced Nox4 activation and MUC8 gene overexpression in human airway epithelial cells.

Authors: Kim, HJ  Kim, CH  Ryu, JH  Joo, JH  Lee, SN  Kim, MJ  Lee, JG  Bae, YS  Yoon, JH 
Citation: Kim HJ, etal., Free Radic Biol Med. 2011 May 1;50(9):1039-52. Epub 2011 Jan 19.
Pubmed: (View Article at PubMed) PMID:21255638
DOI: Full-text: DOI:10.1016/j.freeradbiomed.2011.01.014

Reactive oxygen species (ROS) contribute to chronic airway inflammation, and NADPH oxidase (Nox) is an important source of ROS. However, little is known of the role that ROS play in chronic upper respiratory tract inflammation. We investigated the mechanism of ROS generation and its association with mucin gene overexpression in the nasal epithelium. The level of platelet-derived growth factor (PDGF) expression was increased in sinusitis mucosa, and high-level PDGF expression induced intracellular ROS, followed by MUC8 gene overexpression in normal human nasal epithelial cells. Knockdown of Nox4 expression with Nox4 siRNA decreased PDGF-induced intracellular ROS and MUC8 expression. Infection with an adenovirus containing Nox4 cDNA resulted in Nox4 overexpression and increased intracellular levels of ROS and MUC8 expression. PDGF and Nox4 overexpression are essential components of intracellular ROS generation and may contribute to chronic inflammation in the nasal epithelium through induction of MUC8 overexpression.


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CRRD Object Information
CRRD ID: 6483060
Created: 2012-05-11
Species: All species
Last Modified: 2012-05-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.