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Gene expression changes of urokinase plasminogen activator and urokinase receptor in rat testes at postnatal stages.

Authors: Huang, DH  Zhao, H  Tian, YH  Li, HG  Ding, XF  Xiong, CL 
Citation: Huang DH, etal., Asian J Androl. 2007 Sep;9(5):679-83.
Pubmed: (View Article at PubMed) PMID:17712486
DOI: Full-text: DOI:10.1111/j.1745-7262.2007.00272.x

AIM: To investigate the gene expression changes of urokinase plasminogen activator (uPA)/urokinase receptor (uPAR) in rat testes at postnatal stages and explore the effects of uPA/uPAR system on the rat spermatogenesis. METHODS: The mRNAs of uPA and uPAR in rat testes were measured by using real-time quantitative polymerase chain reaction (PCR) at postnatal days 0, 5, 10, 15, 21, 28, 35, 42, 49 and 56, respectively. RESULTS: The tendencies of uPA and uPAR mRNA expression were similar at most postnatal stages except for D(0). The expression of uPAR mRNA in rats testes was relatively higher than that of uPA at postnatal D(0), and both were decreased until D(21), increased obviously at postnatal D(28), reached a peak at postnatal D(35), then declined sharply at postnatal D(42) and retained at a low level afterwards. CONCLUSION: The uPA/uPAR system may be strongly linked to spermiation and spermatogenesis via regulating germ cell migration and proliferation, as well as promoting the spermiation and detached residual bodies from the mature spermatids.

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CRRD Object Information
CRRD ID: 6484143
Created: 2012-06-12
Species: All species
Last Modified: 2012-06-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.