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Identification of flap structure-specific endonuclease 1 as a factor involved in long-term memory formation of aversive learning.

Authors: Saavedra-Rodriguez, L  Vazquez, A  Ortiz-Zuazaga, HG  Chorna, NE  Gonzalez, FA  Andres, L  Rodriguez, K  Ramirez, F  Rodriguez, A  Pena de Ortiz, S 
Citation: Saavedra-Rodriguez L, etal., J Neurosci. 2009 May 6;29(18):5726-37.
Pubmed: (View Article at PubMed) PMID:19420241
DOI: Full-text: DOI:10.1523/JNEUROSCI.4033-08.2009

We previously proposed that DNA recombination/repair processes play a role in memory formation. Here, we examined the possible role of the fen-1 gene, encoding a flap structure-specific endonuclease, in memory consolidation of conditioned taste aversion (CTA). Quantitative real-time PCR showed that amygdalar fen-1 mRNA induction was associated to the central processing of the illness experience related to CTA and to CTA itself, but not to the central processing resulting from the presentation of a novel flavor. CTA also increased expression of the Fen-1 protein in the amygdala, but not the insular cortex. In addition, double immunofluorescence analyses showed that amygdalar Fen-1 expression is mostly localized within neurons. Importantly, functional studies demonstrated that amygdalar antisense knockdown of fen-1 expression impaired consolidation, but not short-term memory, of CTA. Overall, these studies define the fen-1 endonuclease as a new DNA recombination/repair factor involved in the formation of long-term memories.


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CRRD Object Information
CRRD ID: 6484211
Created: 2012-06-13
Species: All species
Last Modified: 2012-06-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.