beta 2-Syntrophin: localization at the neuromuscular junction in skeletal muscle.

Authors: Peters, MF  Kramarcy, NR  Sealock, R  Froehner, SC 
Citation: Peters MF, etal., Neuroreport. 1994 Aug 15;5(13):1577-80.
Pubmed: (View Article at PubMed) PMID:7819523

The syntrophins are a multigene family of proteins which bind C-terminal domains of dystrophin, utrophin and homologs thereof. We report here that antibodies specific for one isoform, beta 2-syntrophin, labeled only the neuromuscular junction (NMJ) in rat skeletal muscle. Anti-alpha 1-syntrophin antibodies gave strong labeling of the sarcolemma and NMJ in normal rat and mouse muscle, and similar but much weaker labeling in dystrophin-minus mdx muscle. beta 2-Syntrophin therefore appears to be specific to the NMJ in normal muscle, as is utrophin, and may be involved in acetylcholine receptor clustering. alpha 1-Syntrophin appears to be associated mainly with dystrophin, as expected, but a small portion must be associated with another protein, possibly homologs of the electric tissue 87K protein.

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CRRD ID: 6771371
Created: 2012-07-30
Species: All species
Last Modified: 2012-07-30
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.