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The syntaxin family of vesicular transport receptors.

Authors: Bennett, MK  Garcia-Arraras, JE  Elferink, LA  Peterson, K  Fleming, AM  Hazuka, CD  Scheller, RH 
Citation: Bennett MK, etal., Cell 1993 Sep 10;74(5):863-73.
Pubmed: (View Article at PubMed) PMID:7690687

Syntaxins A and B are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. A family of syntaxin-related proteins from rat has been identified that shares 23%-84% amino acid identity. Each of the six syntaxins terminate with a carboxy-terminal hydrophobic domain that anchors the protein on the cytoplasmic surface of cellular membranes. The syntaxins display a broad tissue distribution and, when expressed in COS cells, are targeted to different subcellular compartments. Microinjection studies suggest that the nervous system-specific syntaxin 1A is important for calcium-regulated secretion from neuro-endocrine PC12 cells. These results indicate that the syntaxins are a family of receptors for intracellular transport vesicles and that each target membrane may be identified by a specific member of the syntaxin family.

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CRRD Object Information
CRRD ID: 68313
Created: 2001-07-11
Species: All species
Last Modified: 2001-07-31
Status: ACTIVE



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