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High-sensitivity C-reactive protein: an independent risk factor for left ventricular hypertrophy in patients with lupus nephritis.

Authors: Shi, B  Ni, Z  Cai, H  Zhang, M  Mou, S  Wang, Q  Cao, L  Yu, Z  Yan, Y  Qian, J 
Citation: Shi B, etal., J Biomed Biotechnol. 2010;2010:373426. Epub 2010 Nov 7.
Pubmed: (View Article at PubMed) PMID:21076530
DOI: Full-text: DOI:10.1155/2010/373426

OBJECTIVE: To determine the prevalence of left ventricular hypertrophy (LVH) and its associated risk factors in lupus nephritis (LN) patients. METHODS: 287 LN patients (age: 38.54 +/- 13.31, 262 female) were recruited. Echocardiography and serum high-sensitivity C-reactive protein (hs-CRP) were measured. Their relationship was evaluated by univariate correlation analysis and multivariate regression analysis. RESULTS: The prevalence of LVH in this cohort was 21.25% (n = 61). Serum hs-CRP level was significantly elevated in patients with LVH compared to those without (8.03 (3.22-30.95) versus 3.93 (1.48-9.48) mg/L, P < .01), and correlated with left ventricular mass index (LVMI) (r = 0.314, P = .001). Multivariate regression analysis further confirmed that hs-CRP was an independent risk factor (beta = 0.338, P = .002) for LVH in patients with LN. CONCLUSIONS: Our findings demonstrated that serum hs-CRP level is independently correlated with LVMI and suggested that measurement of hs-CRP may provide important clinical information to investigate LVH in LN patients.

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CRRD Object Information
CRRD ID: 6907433
Created: 2012-11-06
Species: All species
Last Modified: 2012-11-06
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.