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Characterisation of the rat and mouse homologues of gC1qBP, a 33 kDa glycoprotein that binds to the globular 'heads' of C1q.

Authors: Lynch, NJ  Reid, KB  Van den Berg, RH  Daha, MR  Leigh, LA  Ghebrehiwet, B  Lim, WB  Schwaeble, WJ 
Citation: Lynch NJ, etal., FEBS Lett 1997 Nov 24;418(1-2):111-4.
Pubmed: (View Article at PubMed) PMID:9414106

gC1qBP is a 33 kDa glycoprotein that binds to the globular 'heads' of C1q. We have cloned cDNAs encoding the rat and mouse homologues of gC1qBP. Comparison of the cDNA-derived amino acid sequences of gC1qBP reveals that either of the rodent sequences is 89.9% identical to the reported human sequence. Recombinant rat gC1qBP binds avidly to human C1q. gC1qBP mRNA is abundantly expressed in every rat and mouse tissue analysed. Rat mesangial cells synthesise gC1qBP, but do not express gC1qBP on the cell surface. In rat serum, gC1qBP is present at low levels.


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CRRD Object Information
CRRD ID: 69785
Created: 2002-01-08
Species: All species
Last Modified: 2002-01-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.